Physiologic Evaluation of Factors Controlling

Address reprint requests to Dr. Richard N. Bergman, Department of Physiology and Biophysics, University of Southern California School of Medicine, Los Angeles, Calif. 90033. Received for publication 28 November 1980 and in revised form 17 August 1981. 1456 product ofsecond-phase ,-cell responsivity and insulin sensitivity (b2-SI). Thus, these two factors were primarily responsible for overall determination of glucose tolerance. The effect of Xl was to modulate the KG value within those groups whose overall tolerance was determined by 2 SI. This q51 modulating influence was more pronounced among insulin sensitive (4) vs. KG, r = 0.79) than insulin resistant (obese, low tolerance; Xl vs. KG, r = 0.91) subjects. This study demonstrates the feasibility of the minimal model technique to determine the etiology of impaired glucose tolerance.